Published articles - Sánchez Alcázar 's lab

Cilleros-Holgado, P., Gómez-Fernández, D., Piñero-Pérez, R., Romero Domínguez, J. M., Talaverón-Rey, M., Reche-López, D., Suárez-Rivero, J. M., Álvarez-Córdoba, M., Romero-González, A., López-Cabrera, A., Oliveira, M. C., Rodríguez-Sacristan, A., & Sánchez-Alcázar, J. A. (2024). Polydatin and Nicotinamide Rescue the Cellular Phenotype of Mitochondrial Diseases by Mitochondrial Unfolded Protein Response (mtUPR) Activation. Biomolecules, 14(5), 598. https://doi.org/10.3390/biom14050598

Cilleros-Holgado, P., Gómez-Fernández, D., Piñero-Pérez, R., Romero-Domínguez, J. M., Reche-López, D., López-Cabrera, A., Álvarez-Córdoba, M., Munuera-Cabeza, M., Talaverón-Rey, M., Suárez-Carrillo, A., Romero-González, A., & Sánchez-Alcázar, J. A. (2023). Mitochondrial Quality Control via Mitochondrial Unfolded Protein Response (mtUPR) in Ageing and Neurodegenerative Diseases. Biomolecules, 13(12), 1789. https://doi.org/10.3390/biom13121789

Piñero-Pérez, R., López-Cabrera, A., Álvarez-Córdoba, M., Cilleros-Holgado, P., Talaverón-Rey, M., Suárez-Carrillo, A., Munuera-Cabeza, M., Gómez-Fernández, D., Reche-López, D., Romero-González, A., Romero-Domínguez, J. M., de Pablos, R. M., & Sánchez-Alcázar, J. A. (2023). Actin Polymerization Defects Induce Mitochondrial Dysfunction in Cellular Models of Nemaline Myopathies. Antioxidants (Basel, Switzerland), 12(12), 2023. https://doi.org/10.3390/antiox12122023

Álvarez-Córdoba, M., Talaverón-Rey, M., Povea-Cabello, S., Cilleros-Holgado, P., Gómez-Fernández, D., Piñero-Pérez, R., Reche-López, D., Munuera-Cabeza, M., Suárez-Carrillo, A., Romero-González, A., Romero-Domínguez, J. M., López-Cabrera, A., Armengol, J. Á., & Sánchez-Alcázar, J. A. (2023). Patient-Derived Cellular Models for Polytarget Precision Medicine in Pantothenate Kinase-Associated Neurodegeneration. Pharmaceuticals (Basel, Switzerland), 16(10), 1359. https://doi.org/10.3390/ph16101359

Suárez-Carrillo, A., Álvarez-Córdoba, M., Romero-González, A., Talaverón-Rey, M., Povea-Cabello, S., Cilleros-Holgado, P., Piñero-Pérez, R., Reche-López, D., Gómez-Fernández, D., Romero-Domínguez, J. M., Munuera-Cabeza, M., Díaz, A., González-Granero, S., García-Verdugo, J. M., & Sánchez-Alcázar, J. A. (2023). Antioxidants Prevent Iron Accumulation and Lipid Peroxidation, but Do Not Correct Autophagy Dysfunction or Mitochondrial Bioenergetics in Cellular Models of BPAN. International journal of molecular sciences, 24(19), 14576. https://doi.org/10.3390/ijms241914576

Talaverón-Rey, M., Álvarez-Córdoba, M., Villalón-García, I., Povea-Cabello, S., Suárez-Rivero, J. M., Gómez-Fernández, D., Romero-González, A., Suárez-Carrillo, A., Munuera-Cabeza, M., Cilleros-Holgado, P., Reche-López, D., Piñero-Pérez, R., & Sánchez-Alcázar, J. A. (2023). Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels. Orphanet journal of rare diseases, 18(1), 80. https://doi.org/10.1186/s13023-023-02687-5

Suárez-Rivero, J. M., López-Pérez, J., Muela-Zarzuela, I., Pastor-Maldonado, C., Cilleros-Holgado, P., Gómez-Fernández, D., Álvarez-Córdoba, M., Munuera-Cabeza, M., Talaverón-Rey, M., Povea-Cabello, S., Suárez-Carrillo, A., Piñero-Pérez, R., Reche-López, D., Romero-Domínguez, J. M., & Sánchez-Alcázar, J. A. (2023). Neurodegeneration, Mitochondria, and Antibiotics. Metabolites, 13(3), 416. https://doi.org/10.3390/metabo13030416

Cilleros-Holgado P, Gómez-Fernández D, Piñero-Pérez R, Reche-López D, Álvarez-Córdoba M, Munuera-Cabeza M, Talaverón-Rey M, Povea-Cabello S, Suárez-Carrillo A, Romero-González A, Suárez-Rivero JM, Romero-Domínguez JM, Sánchez-Alcázar JA. mtUPR Modulation as a Therapeutic Target for Primary and Secondary Mitochondrial Diseases. International journal of molecular sciences. 2023 Jan 12. doi: https://doi.org/10.3390/ijms24021482

Villalón-García I, Povea-Cabello S, Álvarez-Córdoba M, Talaverón-Rey M, Suárez-Rivero JM, Suárez-Carrillo A, Munuera-Cabeza M, Reche-López D, Cilleros-Holgado P, Piñero-Pérez R, Sánchez-Alcázar, JA. Vicious cycle of lipid peroxidation and iron accumulation in neurodegeneration. Neural regeneration research. 2022 Jan 18. doi: https://doi.org/10.4103/1673-5374.358614

Munuera-Cabeza M, Álvarez-Córdoba M, Suárez-Rivero JM, Povea-Cabello S, Villalón-García I, Talaverón-Rey M, Suárez-Carrillo A, Reche-López D, Cilleros-Holgado P, Piñero-Pérez R, Sánchez-Alcázar JA. Pantothenate and L-Carnitine Supplementation Improves Pathological Alterations in Cellular Models of KAT6A Syndrome. Genes. 2022 Dec 6. doi: https://doi.org/10.3390/genes13122300

Álvarez-Córdoba M, Reche-López D, Cilleros-Holgado P, Talaverón-Rey M, Villalón-García I, Suárez-Rivero JM, Suárez-Carrillo A, Munuera-Cabeza M, Piñero-Pérez R, Sánchez-Alcázar JA. Therapeutic approach with commercial supplements for pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels. Orphanet J Rare Dis. 2022 Aug 17. doi: https://doi.org/10.1186/s13023-022-02465-9

Suárez-Rivero JM, Pastor-Maldonado CJ, Povea-Cabello S, Álvarez-Córdoba M, Villalón-García I, Talaverón-Rey M, Suárez-Carrillo A, Munuera-Cabeza M, Reche-López D, Cilleros-Holgado P, Piñero-Pérez R, Sánchez-Alcázar JA. Activation of the Mitochondrial Unfolded Protein Response: A New Therapeutic Target?. Biomedicines. 2022 Jul 6. doi:10.3390/biomedicines10071611

Povea-Cabello S, Villanueva-Paz M, Villalón-García I, Talaverón-Rey M, Álvarez-Cordoba M, Suárez-Rivero JM, Montes MÁ, Rodríguez-Moreno A, Andrade-Talavera Y, Armengol JA, Sánchez-Alcázar JA. Modeling Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes Syndrome Using Patient-Derived Induced Neurons Generated by Direct Reprogramming. Cell Reprogram. 2022 Jul 8. doi: 10.1089/cell.2022.0055. Online ahead of print. PMID: 35802497

Suárez-Rivero JM, Pastor-Maldonado CJ, Povea-Cabello S, Álvarez-Córdoba M, Villalón-García I, Talaverón-Rey M, Suárez-Carrillo A, Munuera-Cabeza M, Reche-López D, Cilleros-Holgado P, Piñero-Pérez R, Sánchez-Alcázar JA. UPRmt activation improves pathological alterations in cellular models of mitochondrial diseases. Orphanet Journal of Rare Diseases. 2022 May 17(1):204. doi: 10.1186/s13023-022-02331-8.

Suárez-Rivero JM, Pastor-Maldonado CJ, Romero-González A, Gómez-Fernández D, Povea-Cabello S, Álvarez-Córdoba M, Villalón-García I, Talaverón-Rey M, Suárez-Carrillo A, Munuera-Cabeza M, Sánchez-Alcázar JA. Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases. Frontiers in Pharmacology. 2022 March 13:862085. doi: 10.3389/fphar.2022.862085.

Vitamin E prevents lipid peroxidation and iron accumulation in PLA2G6-Associated Neurodegeneration. Villalón-García I, Álvarez-Córdoba M, Povea-Cabello S, Talaverón-Rey M, Villanueva-Paz M, Luzón-Hidalgo R, Suárez-Rivero JM, Suárez-Carrillo A, Munuera-Cabeza M, Salas JJ, Falcón-Moya R, Rodríguez-Moreno A, Armengol JA, Sánchez-Alcázar JA. Neurobiol Dis. 2022 Feb 2:105649. doi: 10.1016/j.nbd.2022.105649.

Mitochondria and Antibiotics: For Good or for Evil? Suárez-Rivero JM, Pastor-Maldonado CJ, Povea-Cabello S, Álvarez-Córdoba M, Villalón-García I, Talaverón-Rey M, Suárez-Carrillo A, Munuera-Cabeza M, Sánchez-Alcázar JA. Biomolecules. 2021 Jul 17;11(7):1050. doi: 10.3390/biom11071050.

Down regulation of the expression of mitochondrial phosphopantetheinyl-proteins in pantothenate kinase-associated neurodegeneration: pathophysiological consequences and therapeutic perspectives. Álvarez-Córdoba M, Talaverón-Rey M, Villalón-García I, Povea-Cabello S, Suárez-Rivero JM, Suárez-Carrillo A, Munuera-Cabeza M, Salas JJ, Sánchez-Alcázar JA. Orphanet J Rare Dis. 2021 May 5;16(1):201. doi: 10.1186/s13023-021-01823-3.

From Mitochondria to Atherosclerosis: The Inflammation Path. Suárez-Rivero JM, Pastor-Maldonado CJ, Povea-Cabello S, Álvarez-Córdoba M, Villalón-García I, Talaverón-Rey M, Suárez-Carrillo A, Munuera-Cabeza M, Sánchez-Alcázar JA. Biomedicines. 2021 Mar 5;9(3):258. doi: 10.3390/biomedicines9030258.

Coenzyme Q₁₀ Analogues: Benefits and Challenges for Therapeutics. Suárez-Rivero JM, Pastor-Maldonado CJ, Povea-Cabello S, Álvarez-Córdoba M, Villalón-García I, Munuera-Cabeza M, Suárez-Carrillo A, Talaverón-Rey M, Sánchez-Alcázar JA. Antioxidants (Basel). 2021 Feb 4;10(2):236. doi: 10.3390/antiox10020236.

Advances in mt-tRNA Mutation-Caused Mitochondrial Disease Modeling: Patients’ Brain in a Dish. Povea-Cabello S, Villanueva-Paz M, Suárez-Rivero JM, Álvarez-Córdoba M, Villalón-García I, Talaverón-Rey M, Suárez-Carrillo A, Munuera-Cabeza M, Sánchez-Alcázar JA. Front Genet. 2021 Jan 12;11:610764. doi: 10.3389/fgene.2020.610764.

Precision Medicine in Rare Diseases. Villalón-García I, Álvarez-Córdoba M, Suárez-Rivero JM, Povea-Cabello S, Talaverón-Rey M, Suárez-Carrillo A, Munuera-Cabeza M, Sánchez-Alcázar JA. Diseases. 2020 Nov 13;8(4):42. doi: 10.3390/diseases8040042.

Coenzyme Q₁₀: Novel Formulations and Medical Trends. Pastor-Maldonado CJ, Suárez-Rivero JM, Povea-Cabello S, Álvarez-Córdoba M, Villalón-García I, Munuera-Cabeza M, Suárez-Carrillo A, Talaverón-Rey M, Sánchez-Alcázar JA. Int J Mol Sci. 2020 Nov 10;21(22):8432. doi: 10.3390/ijms21228432.

Mitochondrial Imbalance as a New Approach to the Study of Fibromyalgia. Martínez-Lara A, Moreno-Fernández AM, Jiménez-Guerrero M, Díaz-López C, De-Miguel M, Cotán D, Sánchez-Alcázar JA. Open Access Rheumatol. 2020 Aug 24;12:175-185. doi: 10.2147/OARRR.S257470.

Lacosamide intake during pregnancy increases the incidence of foetal malformations and symptoms associated with schizophrenia in the offspring of mice. López-Escobar B, Fernández-Torres R, Vargas-López V, Villar-Navarro M, Rybkina T, Rivas-Infante E, Hernández-Viñas A, Álvarez Del Vayo C, Caro-Vega J, Sánchez-Alcázar JA, González-Meneses A, Carrión MÁ, Ybot-González P. Sci Rep. 2020 May 6;10(1):7615. doi: 10.1038/s41598-020-64626-9.

Parkin-mediated mitophagy and autophagy flux disruption in cellular models of MERRF syndrome. Villanueva-Paz M, Povea-Cabello S, Villalón-García I, Álvarez-Córdoba M, Suárez-Rivero JM, Talaverón-Rey M, Jackson S, Falcón-Moya R, Rodríguez-Moreno A, Sánchez-Alcázar JA. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165726. doi: 10.1016/j.bbadis.2020.165726.

Atherosclerosis and Coenzyme Q10. Suárez-Rivero JM, Pastor-Maldonado CJ, de la Mata M, Villanueva-Paz M, Povea-Cabello S, Álvarez-Córdoba M, Villalón-García I, Suárez-Carrillo A, Talaverón-Rey M, Munuera M, Sánchez-Alcázar JA. Int J Mol Sci. 2019 Oct 20;20(20):5195. doi: 10.3390/ijms20205195.

The MELAS mutation m.3243A>G alters the expression of mitochondrial tRNA fragments. Meseguer S, Navarro-González C, Panadero J, Villarroya M, Boutoual R, Sánchez-Alcázar JA, Armengod ME. Biochim Biophys Acta Mol Cell Res. 2019 Sep;1866(9):1433-1449. doi: 10.1016/j.bbamcr.2019.06.004.

Precision medicine in pantothenate kinase-associated neurodegeneration. Alvarez-Cordoba M, Villanueva-Paz M, Villalón-García I, Povea-Cabello S, Suárez-Rivero JM, Talaverón-Rey M, Abril-Jaramillo J, Vintimilla-Tosi AB, Sánchez-Alcázar JA. Precision medicine in pantothenate kinase-associated neurodegeneration. Neural Regen Res. 2019 Jul;14(7):1177-1185. doi: 10.4103/1673-5374.251203.

Pathophysiological characterization of MERRF patient-specific induced neurons generated by direct reprogramming. Villanueva-Paz M, Povea-Cabello S, Villalón-García I, Suárez-Rivero JM, Álvarez-Córdoba M, de la Mata M, Talaverón-Rey M, Jackson S, Sánchez-Alcázar JA. Biochim Biophys Acta Mol Cell Res. 2019 May;1866(5):861-881. doi: 10.1016/j.bbamcr.2019.02.010.

Intracellular cholesterol accumulation and coenzyme Q10 deficiency in Familial Hypercholesterolemia. Suárez-Rivero JM, de la Mata M, Pavón AD, Villanueva-Paz M, Povea-Cabello S, Cotán D, Álvarez-Córdoba M, Villalón-García I, Ybot-González P, Salas JJ, Muñiz O, Cordero MD, Sánchez-Alcázar JA. Biochim Biophys Acta Mol Basis Dis. 2018 Dec;1864(12):3697-3713. doi: 10.1016/j.bbadis.2018.10.009.

Pantothenate Rescues Iron Accumulation in Pantothenate Kinase-Associated Neurodegeneration Depending on the Type of Mutation. Álvarez-Córdoba M, Fernández Khoury A, Villanueva-Paz M, Gómez-Navarro C, Villalón-García I, Suárez-Rivero JM, Povea-Cabello S, de la Mata M, Cotán D, Talaverón-Rey M, Pérez-Pulido AJ, Salas JJ, Pérez-Villegas EM, Díaz-Quintana A, Armengol JA, Sánchez-Alcázar JA. Mol Neurobiol. 2019 May;56(5):3638-3656. doi: 10.1007/s12035-018-1333-0.

Dynamic Reorganization of the Cytoskeleton during Apoptosis: The Two Coffins Hypothesis.Povea-Cabello S, Oropesa-Ávila M, de la Cruz-Ojeda P, Villanueva-Paz M, de la Mata M, Suárez-Rivero JM, Álvarez-Córdoba M, Villalón-García I, Cotán D, Ybot-González P, Sánchez-Alcázar JA. Int J Mol Sci. 2017 Nov 11;18(11):2393. doi: 10.3390/ijms18112393.

Mitochondrial Dynamics in Mitochondrial Diseases. Suárez-Rivero JM, Villanueva-Paz M, de la Cruz-Ojeda P, de la Mata M, Cotán D, Oropesa-Ávila M, de Lavera I, Álvarez-Córdoba M, Luzón-Hidalgo R, Sánchez-Alcázar JA. Diseases. 2016 Dec 23;5(1):1. doi: 10.3390/diseases5010001.

Coenzyme Q10 partially restores pathological alterations in a macrophage model of Gaucher disease. de la Mata M, Cotán D, Oropesa-Ávila M, Villanueva-Paz M, de Lavera I, Álvarez-Córdoba M, Luzón-Hidalgo R, Suárez-Rivero JM, Tiscornia G, Sánchez-Alcázar JA. Orphanet J Rare Dis. 2017 Feb 6;12(1):23. doi: 10.1186/s13023-017-0574-8.

Two coffins and a funeral: early or late caspase activation determines two types of apoptosis induced by DNA damaging agents. Oropesa-Ávila M, de la Cruz-Ojeda P, Porcuna J, Villanueva-Paz M, Fernández-Vega A, de la Mata M, de Lavera I, Rivero JM, Luzón-Hidalgo R, Álvarez-Córdoba M, Cotán D, Zaderenko AP, Cordero MD, Sánchez-Alcázar JA. Apoptosis. 2017 Mar;22(3):421-436. doi: 10.1007/s10495-016-1337-z.

AMPK Regulation of Cell Growth, Apoptosis, Autophagy, and Bioenergetics. Villanueva-Paz M, Cotán D, Garrido-Maraver J, Oropesa-Ávila M, de la Mata M, Delgado-Pavón A, de Lavera I, Alcocer-Gómez E, Álvarez-Córdoba M, Sánchez-Alcázar JA. Exp Suppl. 2016;107:45-71. doi: 10.1007/978-3-319-43589-3_3.

Amitriptyline induces mitophagy that precedes apoptosis in human HepG2 cells. Villanueva-Paz M, Cordero MD, Pavón AD, Vega BC, Cotán D, De la Mata M, Oropesa-Ávila M, Alcocer-Gomez E, de Lavera I, Garrido-Maraver J, Carrascosa J, Zaderenko AP, Muntané J, de Miguel M, Sánchez-Alcázar JA. Genes Cancer. 2016 Jul;7(7-8):260-277. doi: 10.18632/genesandcancer.114.

The Connections Among Autophagy, Inflammasome and Mitochondria. de Lavera I, Pavon AD, Paz MV, Oropesa-Avila M, de la Mata M, Alcocer-Gomez E, Garrido-Maraver J, Cotan D, Alvarez-Cordoba M, Sanchez-Alcazar JA. Curr Drug Targets. 2017;18(9):1030-1038. doi: 10.2174/1389450117666160527143143.

Mitochondrial Myopathy in Follow-up of a Patient With Chronic Fatigue Syndrome. Galán F, de Lavera I, Cotán D, Sánchez-Alcázar JA. J Investig Med High Impact Case Rep. 2015 Sep 24;3(3):2324709615607908. doi: 10.1177/2324709615607908.

AMPK As A Target in Rare Diseases. Cotán D, Paz MV, Alcocer-Gómez E, Garrido-Maraver J, Oropesa-Ávila M, de la Mata M, Pavón AD, de Lavera I, Galán F, Ybot-González P, Sánchez-Alcázar JA.Curr Drug Targets. 2016;17(8):921-31. doi: 10.2174/1389450117666160112110204.

Targeting autophagy and mitophagy for mitochondrial diseases treatment. Villanueva Paz M, Cotán D, Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, de La Mata M, Delgado Pavón A, de Lavera I, Alcocer-Gómez E, Sánchez-Alcázar JA. Expert Opin Ther Targets. 2016;20(4):487-500. doi: 10.1517/14728222.2016.1101068.

Emerging roles of apoptotic microtubules during the execution phase of apoptosis. Oropesa Ávila M, Fernández Vega A, Garrido Maraver J, Villanueva Paz M, De Lavera I, De La Mata M, Cordero MD, Alcocer Gómez E, Delgado Pavón A, Álvarez Córdoba M, Cotán D, Sánchez-Alcázar JA. Cytoskeleton (Hoboken). 2015 Sep;72(9):435-46. doi: 10.1002/cm.21254.

Critical role of AMP-activated protein kinase in the balance between mitophagy and mitochondrial biogenesis in MELAS disease. Garrido-Maraver J, Paz MV, Cordero MD, Bautista-Lorite J, Oropesa-Ávila M, de la Mata M, Pavón AD, de Lavera I, Alcocer-Gómez E, Galán F, Ybot González P, Cotán D, Jackson S, Sánchez-Alcázar JA. Biochim Biophys Acta. 2015 Nov;1852(11):2535-53. doi: 10.1016/j.bbadis.2015.08.027.

Pharmacological Chaperones and Coenzyme Q10 Treatment Improves Mutant β-Glucocerebrosidase Activity and Mitochondrial Function in Neuronopathic Forms of Gaucher Disease. de la Mata M, Cotán D, Oropesa-Ávila M, Garrido-Maraver J, Cordero MD, Villanueva Paz M, Delgado Pavón A, Alcocer-Gómez E, de Lavera I, Ybot-González P, Paula Zaderenko A, Ortiz Mellet C, García Fernández JM, Sánchez-Alcázar JA.. Sci Rep. 2015 Jun 5;5:10903. doi: 10.1038/srep10903.

Coenzyme q10 therapy. Garrido-Maraver J, Cordero MD, Oropesa-Ávila M, Fernández Vega A, de la Mata M, Delgado Pavón A, de Miguel M, Pérez Calero C, Villanueva Paz M, Cotán D, Sánchez-Alcázar JA. Mol Syndromol. 2014 Jul;5(3-4):187-97. doi: 10.1159/000360101.

Stabilization of apoptotic cells: generation of zombie cells. Oropesa-Ávila M, Andrade-Talavera Y, Garrido-Maraver J, Cordero MD, de la Mata M, Cotán D, Paz MV, Pavón AD, Alcocer-Gómez E, de Lavera I, Lema R, Zaderenko AP, Rodríguez-Moreno A, Sánchez-Alcázar JA. Cell Death Dis. 2014 Aug 14;5(8):e1369. doi: 10.1038/cddis.2014.332.

Apoptotic cells subjected to cold/warming exposure disorganize apoptotic microtubule network and undergo secondary necrosis.Oropesa-Ávila M, Fernández-Vega A, de la Mata M, Garrido-Maraver J, Cotán D, Paz MV, Pavón AD, Cordero MD, Alcocer-Gómez E, de Lavera I, Lema R, Zaderenko AP, Sánchez-Alcázar JA. Apoptosis. 2014 Sep;19(9):1364-77. doi: 10.1007/s10495-014-1015-y.

Clinical applications of coenzyme Q10. Garrido-Maraver J, Cordero MD, Oropesa-Avila M, Vega AF, de la Mata M, Pavon AD, Alcocer-Gomez E, Calero CP, Paz MV, Alanis M, de Lavera I, Cotan D, Sanchez-Alcazar JA. Front Biosci (Landmark Ed). 2014 Jan 1;19(4):619-33. doi: 10.2741/4231.

Autophagy researchers. Abeliovich H, Chen Q, Devenish R, Gustafsson A, Sánchez Alcázar JA. Autophagy. 2013 Nov 1;9(11):1648-52. doi: 10.4161/auto.26359.

NLRP3 inflammasome is activated in fibromyalgia: the effect of coenzyme Q10. Cordero MD, Alcocer-Gómez E, Culic O, Carrión AM, de Miguel M, Díaz-Parrado E, Pérez-Villegas EM, Bullón P, Battino M, Sánchez-Alcazar JA. Antioxid Redox Signal. 2014 Mar 10;20(8):1169-80. doi: 10.1089/ars.2013.5198.

Apoptotic microtubules delimit an active caspase free area in the cellular cortex during the execution phase of apoptosis.Oropesa-Ávila M, Fernández-Vega A, de la Mata M, Maraver JG, Cordero MD, Cotán D, de Miguel M, Calero CP, Paz MV, Pavón AD, Sánchez MA, Zaderenko AP, Ybot-González P, Sánchez-Alcázar JA. Cell Death Dis. 2013 Mar 7;4(3):e527. doi: 10.1038/cddis.2013.58.

Can coenzyme q10 improve clinical and molecular parameters in fibromyalgia? Cordero MD, Alcocer-Gómez E, de Miguel M, Culic O, Carrión AM, Alvarez-Suarez JM, Bullón P, Battino M, Fernández-Rodríguez A, Sánchez-Alcazar JA. Antioxid Redox Signal. 2013 Oct 20;19(12):1356-61. doi: 10.1089/ars.2013.5260.

Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient. Cordero MD, Cotán D, del-Pozo-Martín Y, Carrión AM, de Miguel M, Bullón P, Sánchez-Alcazar JA. Nutrition. 2012 Nov-Dec;28(11-12):1200-3. doi: 10.1016/j.nut.2012.03.018.

Screening of effective pharmacological treatments for MELAS syndrome using yeasts, fibroblasts and cybrid models of the disease. Garrido-Maraver J, Cordero MD, Moñino ID, Pereira-Arenas S, Lechuga-Vieco AV, Cotán D, De la Mata M, Oropesa-Ávila M, De Miguel M, Bautista Lorite J, Rivas Infante E, Alvarez-Dolado M, Navas P, Jackson S, Francisci S, Sánchez-Alcázar JA. Br J Pharmacol. 2012 Nov;167(6):1311-28. doi: 10.1111/j.1476-5381.2012.02086.x.

Oxidative stress correlates with headache symptoms in fibromyalgia: coenzyme Q₁₀ effect on clinical improvement. Cordero MD, Cano-García FJ, Alcocer-Gómez E, De Miguel M, Sánchez-Alcázar JA. PLoS One. 2012;7(4):e35677. doi: 10.1371/journal.pone.0035677.

Recovery of MERRF fibroblasts and cybrids pathophysiology by coenzyme Q10. De la Mata M, Garrido-Maraver J, Cotán D, Cordero MD, Oropesa-Ávila M, Izquierdo LG, De Miguel M, Lorite JB, Infante ER, Ybot P, Jackson S, Sánchez-Alcázar JA. Neurotherapeutics. 2012 Apr;9(2):446-63. doi: 10.1007/s13311-012-0103-3.

Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma. Cordero MD, Alcocer-Gómez E, Cano-García FJ, De Miguel M, Carrión AM, Navas P, Sánchez Alcázar JA. PLoS One. 2011;6(10):e26915. doi: 10.1371/journal.pone.0026915.

Secondary coenzyme Q10 deficiency triggers mitochondria degradation by mitophagy in MELAS fibroblasts. Cotán D, Cordero MD, Garrido-Maraver J, Oropesa-Ávila M, Rodríguez-Hernández A, Gómez Izquierdo L, De la Mata M, De Miguel M, Lorite JB, Infante ER, Jackson S, Navas P, Sánchez-Alcázar JA. FASEB J. 2011 Aug;25(8):2669-87. doi: 10.1096/fj.10-165340.

Coenzyme Q(10): a novel therapeutic approach for Fibromyalgia? case series with 5 patients.Cordero MD, Alcocer-Gómez E, de Miguel M, Cano-García FJ, Luque CM, Fernández-Riejo P, Fernández AM, Sánchez-Alcazar JA. Mitochondrion. 2011 Jul;11(4):623-5. doi: 10.1016/j.mito.2011.03.122.

Apoptotic microtubule network organization and maintenance depend on high cellular ATP levels and energized mitochondria. Oropesa M, de la Mata M, Maraver JG, Cordero MD, Cotán D, Rodríguez-Hernández A, Domínguez-Moñino I, de Miguel M, Navas P, Sánchez-Alcázar JA. Apoptosis. 2011 Apr;16(4):404-24. doi: 10.1007/s10495-011-0577-1.

Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease. Cordero MD, De Miguel M, Moreno Fernández AM, Carmona López IM, Garrido Maraver J, Cotán D, Gómez Izquierdo L, Bonal P, Campa F, Bullon P, Navas P, Sánchez Alcázar JA. Arthritis Res Ther. 2010;12(1):R17. doi: 10.1186/ar2918.

Coenzyme Q10 and alpha-tocopherol protect against amitriptyline toxicity. Cordero MD, Moreno-Fernández AM, Gomez-Skarmeta JL, de Miguel M, Garrido-Maraver J, Oropesa-Avila M, Rodríguez-Hernández A, Navas P, Sánchez-Alcázar JA. Toxicol Appl Pharmacol. 2009 Mar 15;235(3):329-37. doi: 10.1016/j.taap.2008.12.026.

Coenzyme Q deficiency triggers mitochondria degradation by mitophagy. Rodríguez-Hernández A, Cordero MD, Salviati L, Artuch R, Pineda M, Briones P, Gómez Izquierdo L, Cotán D, Navas P, Sánchez-Alcázar JA. Autophagy. 2009 Jan;5(1):19-32. doi: 10.4161/auto.5.1.7174.

Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines. Brea-Calvo G, Rodríguez-Hernández A, Fernández-Ayala DJ, Navas P, Sánchez-Alcázar JA. Free Radic Biol Med. 2006 Apr 15;40(8):1293-302. doi: 10.1016/j.freeradbiomed.2005.11.014.

Nuclear caspase-3 and caspase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis. Rodríguez-Hernández A, Brea-Calvo G, Fernández-Ayala DJ, Cordero M, Navas P, Sánchez-Alcázar JA. Apoptosis. 2006 Jan;11(1):131-9. doi: 10.1007/s10495-005-3276-y.